[HTML][HTML] Inflammasome activation has an important role in the development of spontaneous colitis
J Zhang, S Fu, S Sun, Z Li, B Guo - Mucosal immunology, 2014 - Elsevier
Inflammatory bowel disease (IBD) is characterized for dysregulated intestinal inflammation.
Conflicting reports have shown that activation of inflammasome could promote or decrease
intestinal inflammation in an acute colitis model, whereas the involvement of inflammasome
activation in chronic colitis is poorly understood. In this study, we investigated the role of
inflammasome activation in the development of chronic intestinal inflammation by utilizing
interleukin-10 (IL-10) knockout (KO) mouse as an animal model, which develops chronic …
Conflicting reports have shown that activation of inflammasome could promote or decrease
intestinal inflammation in an acute colitis model, whereas the involvement of inflammasome
activation in chronic colitis is poorly understood. In this study, we investigated the role of
inflammasome activation in the development of chronic intestinal inflammation by utilizing
interleukin-10 (IL-10) knockout (KO) mouse as an animal model, which develops chronic …