The role of mast cells in the development of skin fibrosis in tight-skin mutant mice
ET Everett, JL Pablos, RA Harley, EC LeRoy… - … and Physiology Part A …, 1995 - Elsevier
Chronic inflammatory conditions can evolve a fibrotic phenotype often associated with an
increase in the number of mast cells (MC) near or within the granulation tissue. Despite the
potential of MC to mediate fibrosis, it is unclear whether these cells play a central role in the
pathogenesis of ibrosis or whether their presence is simply circumstantial. The tight-skin
(Tsk) mouse develops an inherited fibrotic disease (sharing many similarties with the human
disease scleroderma, systemic sclerosis) in which the lesions are associated with increased …
increase in the number of mast cells (MC) near or within the granulation tissue. Despite the
potential of MC to mediate fibrosis, it is unclear whether these cells play a central role in the
pathogenesis of ibrosis or whether their presence is simply circumstantial. The tight-skin
(Tsk) mouse develops an inherited fibrotic disease (sharing many similarties with the human
disease scleroderma, systemic sclerosis) in which the lesions are associated with increased …