Severe sepsis is almost invariably associated with systemic activation of coagulation. There
is ample evidence that demonstrates a wide-ranging cross-talk between hemostasis and
inflammation, which is probably implicated in the pathogenesis of organ dysfunction in
patients with sepsis. Inflammation not only leads to initiation and propagation of coagulation
activity, but coagulation also markedly influences inflammation. Molecular mechanisms that
play a role in inflammation-induced effects on coagulation have been recognized in much …