Idiopathic nephrotic syndrome is characterized by glomerular proteinuria in the absence of
infiltrating cells or immunoglobulin deposits. Although it is suspected that T cells secrete a
circulating factor that leads to proteinuria by altering the permeability of the glomerular
filtration barrier, the precise etiology of this syndrome is unknown. Because an animal model
that mimics human idiopathic nephrotic syndrome does not exist, we developed a
humanized mouse model of the disease by injecting CD34+ stem cells or CD34− peripheral …