Autoinflammatory skin disorders: the inflammasome in focus

P Gurung, TD Kanneganti - Trends in molecular medicine, 2016 - cell.com
Trends in molecular medicine, 2016cell.com
Autoinflammatory skin disorders are a group of heterogeneous diseases that include
diseases such as cryopyrin-associated periodic syndrome (CAPS) and familial
Mediterranean fever (FMF). Therapeutic strategies targeting IL-1 cytokines have proved
helpful in ameliorating some of these diseases. While inflammasomes are the major
regulators of IL-1 cytokines, inflammasome-independent complexes can also process IL-1
cytokines. Herein, we focus on recent advances in our understanding of how IL-1 cytokines …
Autoinflammatory skin disorders are a group of heterogeneous diseases that include diseases such as cryopyrin-associated periodic syndrome (CAPS) and familial Mediterranean fever (FMF). Therapeutic strategies targeting IL-1 cytokines have proved helpful in ameliorating some of these diseases. While inflammasomes are the major regulators of IL-1 cytokines, inflammasome-independent complexes can also process IL-1 cytokines. Herein, we focus on recent advances in our understanding of how IL-1 cytokines, stemming from inflammasome-dependent and -independent pathways are involved in the regulation of skin conditions. Importantly, we discuss several mouse models of skin inflammation generated to help elucidate the basic cellular and molecular effects and modulation of IL-1 in the skin. Such models offer perspectives on how these signaling pathways could be targeted to improve therapeutic approaches in the treatment of these rare and debilitating inflammatory skin disorders.
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