Stress-induced microglial activation may facilitate the progression of neurodegenerative disorders

S Sugama - Medical hypotheses, 2009 - Elsevier
Microglial activation has been associated with various clinical disorders. In particular,
activated microglia have been reported in various brain regions, including the hippocampus,
substantia nigra, striatum, and cerebral cortex, in which significant neurodegeneration
occurs in various neurodegenerative disorders. Our previous study demonstrated that acute
stress, restraint combined with water immersion, substantially induces massive microglial
activation in the brain, particularly in the hippocampus, hypothalamus, thalamus, and …