The knock-down of ERCC1 but not of XPF causes multinucleation
J Rageul, C Frėmin, F Ezan, G Baffet, S Langouėt - DNA repair, 2011 - Elsevier
Excision repair cross complementing gene 1 (ERCC1) associated with xeroderma
pigmentosum group F (XPF) is a heterodimeric endonuclease historically involved in the
excision of bulky helix-distorting DNA lesions during nucleotide excision repair (NER) but
also in the repair of DNA interstrand crosslinks. ERCC1 deficient mice show severe growth
retardation associated with premature replicative senescence leading to liver failure and
death at four weeks of age. In humans, ERCC1 is overexpressed in hepatocellular …
pigmentosum group F (XPF) is a heterodimeric endonuclease historically involved in the
excision of bulky helix-distorting DNA lesions during nucleotide excision repair (NER) but
also in the repair of DNA interstrand crosslinks. ERCC1 deficient mice show severe growth
retardation associated with premature replicative senescence leading to liver failure and
death at four weeks of age. In humans, ERCC1 is overexpressed in hepatocellular …