[HTML][HTML] Dose-dependent effects of icilin on thermal preference in the hindpaw and face of rats
HL Rossi, CJ Vierck Jr, RM Caudle, RP Yezierski… - The Journal of …, 2009 - Elsevier
Icilin induces wet dog shakes (WDS) in rodents when injected systemically and activates the
cold receptor TRPM8 and putative cold receptor TRPA1. It is assumed that WDS reflect an
enhanced cold sensitivity; however, none have examined the relationship between WDS
and cutaneous cold sensitivity following systemic icilin. In this study, we sought to
characterize the effect of systemic and central icilin administration on WDS and thermal
preference with either hindpaw or facial stimulation. It was found that a low dose of icilin …
cold receptor TRPM8 and putative cold receptor TRPA1. It is assumed that WDS reflect an
enhanced cold sensitivity; however, none have examined the relationship between WDS
and cutaneous cold sensitivity following systemic icilin. In this study, we sought to
characterize the effect of systemic and central icilin administration on WDS and thermal
preference with either hindpaw or facial stimulation. It was found that a low dose of icilin …