Transcriptional changes in dorsal spinal cord persist after surgical incision despite preemptive analgesia with peripheral resiniferatoxin
SJ Raithel, MR Sapio, DM LaPaglia, MJ Iadarola… - …, 2018 - pubs.asahq.org
Background Peripheral nociceptors expressing the ion channel transient receptor potential
cation channel, subfamily V, member 1, play an important role in mediating postoperative
pain. Signaling from these nociceptors in the peri-and postoperative period can lead to
plastic changes in the spinal cord and, when controlled, can yield analgesia. The
transcriptomic changes in the dorsal spinal cord after surgery, and potential coupling to
transient receptor potential cation channel, subfamily V, member 1–positive nociceptor …
cation channel, subfamily V, member 1, play an important role in mediating postoperative
pain. Signaling from these nociceptors in the peri-and postoperative period can lead to
plastic changes in the spinal cord and, when controlled, can yield analgesia. The
transcriptomic changes in the dorsal spinal cord after surgery, and potential coupling to
transient receptor potential cation channel, subfamily V, member 1–positive nociceptor …