Activation of hepatic lipase catalyzed phosphatidylcholine hydrolysis by apolipoprotein E
T Thuren, P Sisson, M Waite - Biochimica et Biophysica Acta (BBA)-Lipids …, 1991 - Elsevier
The effect of apolipoproteins AI, A-II, C-II, C-III and E on the hydrolysis of
phosphatidylcholine and triacylglycerol by hepatic lipase was studied. Hepatic lipase
catalyzed phospholipid hydrolysis was 1.8-fold activated by apolipoprotein E while the other
apolipoproteins did not affect the hydrolysis by this enzyme. Triacylglycerol hydrolysis by
hepatic lipase was 1.5-fold activated by apolipoprotein E while the other apolipoproteins
inhibited hepatic lipase. These results suggest that lipoproteins containing apolipoprotein E …
phosphatidylcholine and triacylglycerol by hepatic lipase was studied. Hepatic lipase
catalyzed phospholipid hydrolysis was 1.8-fold activated by apolipoprotein E while the other
apolipoproteins did not affect the hydrolysis by this enzyme. Triacylglycerol hydrolysis by
hepatic lipase was 1.5-fold activated by apolipoprotein E while the other apolipoproteins
inhibited hepatic lipase. These results suggest that lipoproteins containing apolipoprotein E …