[HTML][HTML] FGF15/FGFR4 integrates growth factor signaling with hepatic bile acid metabolism and insulin action
DJ Shin, TF Osborne - Journal of Biological Chemistry, 2009 - ASBMB
The current studies show FGF15 signaling decreases hepatic forkhead transcription factor 1
(FoxO1) activity through phosphatidylinositol (PI) 3-kinase-dependent phosphorylation. The
bile acid receptor FXR (farnesoid X receptor) activates expression of fibroblast growth factor
(FGF) 15 in the intestine, which acts through hepatic FGFR4 to suppress cholesterol-7α
hydroxylase (CYP7A1) and limit bile acid production. Because FoxO1 activity and CYP7A1
gene expression are both increased by fasting, we hypothesized CYP7A1 might be a FoxO1 …
(FoxO1) activity through phosphatidylinositol (PI) 3-kinase-dependent phosphorylation. The
bile acid receptor FXR (farnesoid X receptor) activates expression of fibroblast growth factor
(FGF) 15 in the intestine, which acts through hepatic FGFR4 to suppress cholesterol-7α
hydroxylase (CYP7A1) and limit bile acid production. Because FoxO1 activity and CYP7A1
gene expression are both increased by fasting, we hypothesized CYP7A1 might be a FoxO1 …