[HTML][HTML] Scavenger receptor CD36 mediates uptake of high density lipoproteins in mice and by cultured cells [S]
M Brundert, J Heeren, M Merkel, A Carambia… - Journal of lipid …, 2011 - ASBMB
The mechanisms of HDL-mediated cholesterol transport from peripheral tissues to the liver
are incompletely defined. Here the function of scavenger receptor cluster of differentiation 36
(CD36) for HDL uptake by the liver was investigated. CD36 knockout (KO) mice, which were
the model, have a 37% increase (P= 0.008) of plasma HDL cholesterol compared with wild-
type (WT) littermates. To explore the mechanism of this increase, HDL metabolism was
investigated with HDL radiolabeled in the apolipoprotein (125 I) and cholesteryl ester (CE,[3 …
are incompletely defined. Here the function of scavenger receptor cluster of differentiation 36
(CD36) for HDL uptake by the liver was investigated. CD36 knockout (KO) mice, which were
the model, have a 37% increase (P= 0.008) of plasma HDL cholesterol compared with wild-
type (WT) littermates. To explore the mechanism of this increase, HDL metabolism was
investigated with HDL radiolabeled in the apolipoprotein (125 I) and cholesteryl ester (CE,[3 …