[HTML][HTML] Hepatic lipase deficiency decreases the selective uptake of HDL-cholesteryl esters in vivo
G Lambert, MJA Amar, P Martin, J Fruchart-Najib… - Journal of Lipid …, 2000 - ASBMB
Recent in vitro studies have provided evidence that hepatic lipase (HL) facilitates the
selective uptake of HDL cholesteryl esters (CE), but the in vivo physiological relevance of
this process has not been demonstrated. To evaluate the role that HL plays in facilitating the
selective uptake of HDL-CE in vivo, we studied the metabolism of [3 H] CEt, 125 I-labeled
apolipoprotein (apo) AI, and 131 I-labeled apoA-II-labeled HDL in HL-deficient mice. Kinetic
analysis revealed similar catabolism of 125 I-labeled apoA-I (as well as 131 I-labeled apoA …
selective uptake of HDL cholesteryl esters (CE), but the in vivo physiological relevance of
this process has not been demonstrated. To evaluate the role that HL plays in facilitating the
selective uptake of HDL-CE in vivo, we studied the metabolism of [3 H] CEt, 125 I-labeled
apolipoprotein (apo) AI, and 131 I-labeled apoA-II-labeled HDL in HL-deficient mice. Kinetic
analysis revealed similar catabolism of 125 I-labeled apoA-I (as well as 131 I-labeled apoA …