[HTML][HTML] Overexpression of hepatic lipase in transgenic mice decreases apolipoprotein B-containing and high density lipoproteins: evidence that hepatic lipase acts as …

HL Dichek, W Brecht, J Fan, ZS Ji… - Journal of Biological …, 1998 - ASBMB
To determine the mechanisms by which human hepatic lipase (HL) contributes to the
metabolism of apolipoprotein (apo) B-containing lipoproteins and high density lipoproteins
(HDL) in vivo, we developed and characterized HL transgenic mice. HL was localized by
immunohistochemistry to the liver and to the adrenal cortex. In hemizygous (hHLTg+/0) and
homozygous (hHLTg+/+) mice, postheparin plasma HL activity increased by 25-and 50-fold
and plasma cholesterol levels decreased by 80% and 85%, respectively. In mice fed a high …