[HTML][HTML] Heparan sulfate proteoglycans participate in hepatic lipaseand apolipoprotein E-mediated binding and uptake of plasma lipoproteins, including high density …
ZS Ji, HL Dichek, RD Miranda, RW Mahley - Journal of Biological Chemistry, 1997 - ASBMB
High density lipoprotein (HDL) particles and HDL cholesteryl esters are taken up by both
receptor-mediated and non-receptor-mediated pathways. Here we show that cell surface
heparan sulfate proteoglycans (HSPG) participate in hepatic lipase (HL)-and apolipoprotein
(apo) E-mediated binding and uptake of mouse and human HDL by cultured hepatocytes.
The HL secreted by HL-transfected McA-RH7777 cells enhanced both HDL binding at 4° C
(∼ 2–4-fold) and HDL uptake at 37° C (∼ 2–5-fold). The enhanced binding and uptake of …
receptor-mediated and non-receptor-mediated pathways. Here we show that cell surface
heparan sulfate proteoglycans (HSPG) participate in hepatic lipase (HL)-and apolipoprotein
(apo) E-mediated binding and uptake of mouse and human HDL by cultured hepatocytes.
The HL secreted by HL-transfected McA-RH7777 cells enhanced both HDL binding at 4° C
(∼ 2–4-fold) and HDL uptake at 37° C (∼ 2–5-fold). The enhanced binding and uptake of …