[HTML][HTML] Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate β-catenin-dependent gene expression
JS Nam, TJ Turcotte, PF Smith, S Choi… - Journal of Biological …, 2006 - ASBMB
Wnt signaling plays critical biological roles during normal embryonic development and
homeostasis in adults. In the canonical pathway, binding of Wnt ligands to the Frizzled (Fzd)
receptor and the low density lipoprotein-related receptor (LRP) 5 or LRP6 coreceptor
initiates downstream signaling events leading to gene activation by β-catenin and the T-cell
factor (TCF)-lymphoid enhancer factor (LEF) family transcription factor complex. In this study,
we provide several lines of evidence that the mouse Cristin/R-spondin family proteins …
homeostasis in adults. In the canonical pathway, binding of Wnt ligands to the Frizzled (Fzd)
receptor and the low density lipoprotein-related receptor (LRP) 5 or LRP6 coreceptor
initiates downstream signaling events leading to gene activation by β-catenin and the T-cell
factor (TCF)-lymphoid enhancer factor (LEF) family transcription factor complex. In this study,
we provide several lines of evidence that the mouse Cristin/R-spondin family proteins …