[HTML][HTML] Natural killer cell receptor repertoire and their ligands, and the risk of CMV infection after kidney transplantation
K Hadaya, C De Rham, C Bandelier… - American Journal of …, 2008 - Elsevier
Cytomegalovirus (CMV) infection is the most common viral complication after solid organ
transplantation (SOT). Whilst current immunosuppression is known to impair antiviral-
specific T-cell immunity in SOT, a potential role for natural killer (NK) cells not affected by
immunosuppressive therapy remains to be determined. To address this, we compared the
genotype of the NK immunoglobulin-like receptor (KIR) genes and their HLA cognate
ligands to the rate of CMV infection in 196 kidney transplant recipients. We have shown that …
transplantation (SOT). Whilst current immunosuppression is known to impair antiviral-
specific T-cell immunity in SOT, a potential role for natural killer (NK) cells not affected by
immunosuppressive therapy remains to be determined. To address this, we compared the
genotype of the NK immunoglobulin-like receptor (KIR) genes and their HLA cognate
ligands to the rate of CMV infection in 196 kidney transplant recipients. We have shown that …