Immunometabolism governs dendritic cell and macrophage function

LAJ O'Neill, EJ Pearce - Journal of Experimental Medicine, 2016 - rupress.org
LAJ O'Neill, EJ Pearce
Journal of Experimental Medicine, 2016rupress.org
Recent studies on intracellular metabolism in dendritic cells (DCs) and macrophages
provide new insights on the functioning of these critical controllers of innate and adaptive
immunity. Both cell types undergo profound metabolic reprogramming in response to
environmental cues, such as hypoxia or nutrient alterations, but importantly also in response
to danger signals and cytokines. Metabolites such as succinate and citrate have a direct
impact on the functioning of macrophages. Immunogenicity and tolerogenicity of DCs is also …
Recent studies on intracellular metabolism in dendritic cells (DCs) and macrophages provide new insights on the functioning of these critical controllers of innate and adaptive immunity. Both cell types undergo profound metabolic reprogramming in response to environmental cues, such as hypoxia or nutrient alterations, but importantly also in response to danger signals and cytokines. Metabolites such as succinate and citrate have a direct impact on the functioning of macrophages. Immunogenicity and tolerogenicity of DCs is also determined by anabolic and catabolic processes, respectively. These findings provide new prospects for therapeutic manipulation in inflammatory diseases and cancer.
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