Low immature platelet fraction suggests decreased megakaryopoiesis in neonates with sepsis or necrotizing enterocolitis
M Cremer, A Weimann, D Szekessy, H Hammer… - Journal of …, 2013 - nature.com
M Cremer, A Weimann, D Szekessy, H Hammer, C Bührer, C Dame
Journal of Perinatology, 2013•nature.comObjective: In order to conclude on the megakaryopoietic activity during thrombocytopenia in
sepsis or necrotizing enterocolitis (NEC), we analyzed the immature platelet fraction (IPF).
Study design: Serial measurements of platelet counts and IPF in neonates with blood culture-
proven late-onset sepsis (n= 21) or surgical NEC (n= 12) at T0: prior to the diagnosis of
sepsis/NEC; T1: at diagnosis; T2: days 3 to 5 after onset; T3: days 8 to 12 after onset. Result:
In parallel to declining platelet counts, the median absolute IPF significantly decreased …
sepsis or necrotizing enterocolitis (NEC), we analyzed the immature platelet fraction (IPF).
Study design: Serial measurements of platelet counts and IPF in neonates with blood culture-
proven late-onset sepsis (n= 21) or surgical NEC (n= 12) at T0: prior to the diagnosis of
sepsis/NEC; T1: at diagnosis; T2: days 3 to 5 after onset; T3: days 8 to 12 after onset. Result:
In parallel to declining platelet counts, the median absolute IPF significantly decreased …
Abstract
Objective:
In order to conclude on the megakaryopoietic activity during thrombocytopenia in sepsis or necrotizing enterocolitis (NEC), we analyzed the immature platelet fraction (IPF).
Study design:
Serial measurements of platelet counts and IPF in neonates with blood culture-proven late-onset sepsis (n= 21) or surgical NEC (n= 12) at T0: prior to the diagnosis of sepsis/NEC; T1: at diagnosis; T2: days 3 to 5 after onset; T3: days 8 to 12 after onset.
Result:
In parallel to declining platelet counts, the median absolute IPF significantly decreased between T0 and T2 in neonates with sepsis or NEC. We found a significant positive correlation between the platelet count and absolute IPF (r= 0.71; P< 0.001). In patients with low IPF (< 2 per nl), the platelet count did not subsequently increase. Neonates with NEC who died exhibited significantly lower IPF compared with survivors (P< 0.05).
Conclusion:
Low absolute IPF values during the course of neonatal sepsis/NEC suggest suppression of megakaryopoietic activity.
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