Plasma angiopoietin-2 in clinical acute lung injury: prognostic and pathogenetic significance
CS Calfee, D Gallagher, J Abbott… - Critical care …, 2012 - journals.lww.com
Background: Angiopoietin-2 is a proinflammatory mediator of endothelial injury in animal
models, and increased plasma angiopoietin-2 levels are associated with poor outcomes in
patients with sepsis-associated acute lung injury. Whether angiopoietin-2 levels are
modified by treatment strategies in patients with acute lung injury is unknown. Objectives: To
determine whether plasma angiopoietin-2 levels are associated with clinical outcomes and
affected by fluid management strategy in a broad cohort of patients with acute lung injury …
models, and increased plasma angiopoietin-2 levels are associated with poor outcomes in
patients with sepsis-associated acute lung injury. Whether angiopoietin-2 levels are
modified by treatment strategies in patients with acute lung injury is unknown. Objectives: To
determine whether plasma angiopoietin-2 levels are associated with clinical outcomes and
affected by fluid management strategy in a broad cohort of patients with acute lung injury …