IL-6 trans-signaling drives murine crescentic GN
GS Braun, Y Nagayama, Y Maruta… - Journal of the …, 2016 - journals.lww.com
The role of IL-6 signaling in renal diseases remains controversial, with data describing both
anti-inflammatory and proinflammatory effects. IL-6 can act via classic signaling, engaging
its two membrane receptors gp130 and IL-6 receptor (IL-6R). Alternatively, IL-6 trans-
signaling requires soluble IL-6R (sIL-6R) to act on IL-6R-negative cells that express gp130.
Here, we characterize the role of both pathways in crescentic nephritis. Patients with
crescentic nephritis had significantly elevated levels of IL-6 in both serum and urine …
anti-inflammatory and proinflammatory effects. IL-6 can act via classic signaling, engaging
its two membrane receptors gp130 and IL-6 receptor (IL-6R). Alternatively, IL-6 trans-
signaling requires soluble IL-6R (sIL-6R) to act on IL-6R-negative cells that express gp130.
Here, we characterize the role of both pathways in crescentic nephritis. Patients with
crescentic nephritis had significantly elevated levels of IL-6 in both serum and urine …