[HTML][HTML] The epidermal growth factor receptor mediates tumor necrosis factor-α-induced activation of the ERK/GEF-H1/RhoA pathway in tubular epithelium
E Kakiashvili, Q Dan, M Vandermeer, Y Zhang… - Journal of Biological …, 2011 - ASBMB
Tumor necrosis factor (TNF)-α induces cytoskeleton and intercellular junction remodeling in
tubular epithelial cells; the underlying mechanisms, however, are incompletely explored. We
have previously shown that ERK-mediated stimulation of the RhoA GDP/GTP exchange
factor GEF-H1/Lfc is critical for TNF-α-induced RhoA stimulation. Here we investigated the
upstream mechanisms of ERK/GEF-H1 activation. Surprisingly, TNF-α-induced ERK and
RhoA stimulation in tubular cells were prevented by epidermal growth factor receptor …
tubular epithelial cells; the underlying mechanisms, however, are incompletely explored. We
have previously shown that ERK-mediated stimulation of the RhoA GDP/GTP exchange
factor GEF-H1/Lfc is critical for TNF-α-induced RhoA stimulation. Here we investigated the
upstream mechanisms of ERK/GEF-H1 activation. Surprisingly, TNF-α-induced ERK and
RhoA stimulation in tubular cells were prevented by epidermal growth factor receptor …