Monocyte chemoattractant protein-1 (MCP-1): an overview

SL Deshmane, S Kremlev, S Amini… - Journal of interferon & …, 2009 - liebertpub.com
SL Deshmane, S Kremlev, S Amini, BE Sawaya
Journal of interferon & cytokine research, 2009liebertpub.com
Chemokines constitute a family of chemoattractant cytokines and are subdivided into four
families on the basis of the number and spacing of the conserved cysteine residues in the N-
terminus of the protein. Chemokines play a major role in selectively recruiting monocytes,
neutrophils, and lymphocytes, as well as in inducing chemotaxis through the activation of G-
protein-coupled receptors. Monocyte chemoattractant protein-1 (MCP-1/CCL2) is one of the
key chemokines that regulate migration and infiltration of monocytes/macrophages. Both …
Chemokines constitute a family of chemoattractant cytokines and are subdivided into four families on the basis of the number and spacing of the conserved cysteine residues in the N-terminus of the protein. Chemokines play a major role in selectively recruiting monocytes, neutrophils, and lymphocytes, as well as in inducing chemotaxis through the activation of G-protein-coupled receptors. Monocyte chemoattractant protein-1 (MCP-1/CCL2) is one of the key chemokines that regulate migration and infiltration of monocytes/macrophages. Both CCL2 and its receptor CCR2 have been demonstrated to be induced and involved in various diseases. Migration of monocytes from the blood stream across the vascular endothelium is required for routine immunological surveillance of tissues, as well as in response to inflammation. This review will discuss these biological processes and the structure and function of CCL2.
Mary Ann Liebert