[PDF][PDF] Endoplasmic reticulum stress in malignancy
HJ Clarke, JE Chambers, E Liniker, SJ Marciniak - Cancer cell, 2014 - cell.com
HJ Clarke, JE Chambers, E Liniker, SJ Marciniak
Cancer cell, 2014•cell.comThe combination of relative nutrient deprivation and dysregulation of protein synthesis make
malignant cells especially prone to protein misfolding. Endoplasmic reticulum stress, which
results from protein misfolding within the secretory pathway, has a profound effect on cancer
cell proliferation and survival. In this review, we examine the evidence implicating
endoplasmic reticulum dysfunction in the pathology of cancer and discuss how recent
findings may help to identify novel therapeutic targets.
malignant cells especially prone to protein misfolding. Endoplasmic reticulum stress, which
results from protein misfolding within the secretory pathway, has a profound effect on cancer
cell proliferation and survival. In this review, we examine the evidence implicating
endoplasmic reticulum dysfunction in the pathology of cancer and discuss how recent
findings may help to identify novel therapeutic targets.
The combination of relative nutrient deprivation and dysregulation of protein synthesis make malignant cells especially prone to protein misfolding. Endoplasmic reticulum stress, which results from protein misfolding within the secretory pathway, has a profound effect on cancer cell proliferation and survival. In this review, we examine the evidence implicating endoplasmic reticulum dysfunction in the pathology of cancer and discuss how recent findings may help to identify novel therapeutic targets.
cell.com