[HTML][HTML] Interleukin-6-induced tethering of STAT3 to the LAP/C/EBPβ promoter suggests a new mechanism of transcriptional regulation by STAT3
M Niehof, K Streetz, T Rakemann, SC Bischoff… - Journal of Biological …, 2001 - ASBMB
LAP/C/EBPβ is a member of the C/EBP family of transcription factors and contributes to the
regulation of the acute phase response in hepatocytes. Here we show that IL-6
controlsLAP/C/EBPβ gene transcription and identify an IL-6 responsive element in the
LAP/C/EBPβ promoter, which contains no STAT3 DNA binding motif. However, luciferase
reporter gene assays showed that STAT3 activation through the gp130 signal transducer
molecule is involved in mediating IL-6-dependent LAP/C/EBPβ transcription. Southwestern …
regulation of the acute phase response in hepatocytes. Here we show that IL-6
controlsLAP/C/EBPβ gene transcription and identify an IL-6 responsive element in the
LAP/C/EBPβ promoter, which contains no STAT3 DNA binding motif. However, luciferase
reporter gene assays showed that STAT3 activation through the gp130 signal transducer
molecule is involved in mediating IL-6-dependent LAP/C/EBPβ transcription. Southwestern …