[HTML][HTML] Tumor suppressor and aging biomarker p16INK4a induces cellular senescence without the associated inflammatory secretory phenotype
Cellular senescence suppresses cancer by preventing the proliferation of cells that
experience potentially oncogenic stimuli. Senescent cells often express p16 INK4a, a cyclin-
dependent kinase inhibitor, tumor suppressor, and biomarker of aging, which renders the
senescence growth arrest irreversible. Senescent cells also acquire a complex phenotype
that includes the secretion of many cytokines, growth factors, and proteases, termed a
senescence-associated secretory phenotype (SASP). The SASP is proposed to underlie age …
experience potentially oncogenic stimuli. Senescent cells often express p16 INK4a, a cyclin-
dependent kinase inhibitor, tumor suppressor, and biomarker of aging, which renders the
senescence growth arrest irreversible. Senescent cells also acquire a complex phenotype
that includes the secretion of many cytokines, growth factors, and proteases, termed a
senescence-associated secretory phenotype (SASP). The SASP is proposed to underlie age …