[HTML][HTML] Identification of Akt-independent regulation of hepatic lipogenesis by mammalian target of rapamycin (mTOR) complex 2
Mammalian target of rapamycin complex 2 (mTORC2) is a key activator of protein kinases
that act downstream of insulin and growth factor signaling. Here we report that mice lacking
the essential mTORC2 component rictor in liver (Lrictor KO) are unable to respond normally
to insulin. In response to insulin, Lrictor KO mice failed to inhibit hepatic glucose output.
Lrictor KO mice also fail to develop hepatic steatosis on a high fat diet and manifest half-
normal serum cholesterol levels. This is accompanied by lower levels of expression of …
that act downstream of insulin and growth factor signaling. Here we report that mice lacking
the essential mTORC2 component rictor in liver (Lrictor KO) are unable to respond normally
to insulin. In response to insulin, Lrictor KO mice failed to inhibit hepatic glucose output.
Lrictor KO mice also fail to develop hepatic steatosis on a high fat diet and manifest half-
normal serum cholesterol levels. This is accompanied by lower levels of expression of …