Morphological change is one of the cardinal features of the senescent phenotype; for
example, senescent human diploid cells have a flat large shape. However, the mechanisms
underlying such senescence-related morphological alterations have not been well studied.
To investigate this situation, we characterized the senescence-dependent changes of
cellular structural determinants in terms of their levels and activities. These determinants
included integrins, focal adhesion complexes, and small Rho GTPases, and special …