Intrinsic subtype switching and acquired ERBB2/HER2 amplifications and mutations in breast cancer brain metastases
N Priedigkeit, RJ Hartmaier, Y Chen, D Vareslija… - JAMA …, 2017 - jamanetwork.com
Importance Patients with breast cancer (BrCa) brain metastases (BrM) have limited
therapeutic options. A better understanding of molecular alterations acquired in BrM could
identify clinically actionable metastatic dependencies. Objective To determine whether there
are intrinsic subtype differences between primary tumors and matched BrM and to uncover
BrM-acquired alterations that are clinically actionable. Design, Setting, and Participants In
total, 20 cases of primary breast cancer tissue and resected BrM (10 estrogen receptor [ER] …
therapeutic options. A better understanding of molecular alterations acquired in BrM could
identify clinically actionable metastatic dependencies. Objective To determine whether there
are intrinsic subtype differences between primary tumors and matched BrM and to uncover
BrM-acquired alterations that are clinically actionable. Design, Setting, and Participants In
total, 20 cases of primary breast cancer tissue and resected BrM (10 estrogen receptor [ER] …