[HTML][HTML] Glucagon receptor antagonism induces increased cholesterol absorption [S]
HP Guan, X Yang, K Lu, SP Wang… - Journal of lipid …, 2015 - ASBMB
Glucagon and insulin have opposing action in governing glucose homeostasis. In type 2
diabetes mellitus (T2DM), plasma glucagon is characteristically elevated, contributing to
increased gluconeogenesis and hyperglycemia. Therefore, glucagon receptor (GCGR)
antagonism has been proposed as a pharmacologic approach to treat T2DM. In support of
this concept, a potent small-molecule GCGR antagonist (GRA), MK-0893, demonstrated
dose-dependent efficacy to reduce hyperglycemia, with an HbA 1c reduction of 1.5% at the …
diabetes mellitus (T2DM), plasma glucagon is characteristically elevated, contributing to
increased gluconeogenesis and hyperglycemia. Therefore, glucagon receptor (GCGR)
antagonism has been proposed as a pharmacologic approach to treat T2DM. In support of
this concept, a potent small-molecule GCGR antagonist (GRA), MK-0893, demonstrated
dose-dependent efficacy to reduce hyperglycemia, with an HbA 1c reduction of 1.5% at the …