The vaccine-site microenvironment induced by injection of incomplete Freund's adjuvant, with or without melanoma peptides
RC Harris, KA Chianese-Bullock… - Journal of …, 2012 - journals.lww.com
Cancer vaccines have not been optimized. They depend on adjuvants to create an
immunogenic microenvironment for antigen presentation. However, remarkably little is
understood about cellular and molecular changes induced by these adjuvants in the vaccine
microenvironment. We hypothesized that vaccination induces dendritic cell (DC) activation
in the dermal vaccination microenvironment but that regulatory processes may also limit the
effectiveness of repeated vaccination. We evaluated biopsies from immunization sites in 2 …
immunogenic microenvironment for antigen presentation. However, remarkably little is
understood about cellular and molecular changes induced by these adjuvants in the vaccine
microenvironment. We hypothesized that vaccination induces dendritic cell (DC) activation
in the dermal vaccination microenvironment but that regulatory processes may also limit the
effectiveness of repeated vaccination. We evaluated biopsies from immunization sites in 2 …