Extracellular superoxide dismutase and cardiovascular disease
Cardiovascular research, 2002•academic.oup.com
Excessive production and/or inadequate removal of reactive oxygen species, especially
superoxide anion (O2•−), have been implicated in the pathogenesis of many cardiovascular
diseases, including atherosclerosis, hypertension, diabetes, and in endothelial dysfunction
by decreasing nitric oxide (NO) bioactivity. Since the vascular levels of O2•− are regulated
by the superoxide dismutase (SOD) enzymes, a role of SOD in the cardiovascular disease is
of substantial interest. Particularly, a major form of SOD in the vessel wall is the extracellular …
superoxide anion (O2•−), have been implicated in the pathogenesis of many cardiovascular
diseases, including atherosclerosis, hypertension, diabetes, and in endothelial dysfunction
by decreasing nitric oxide (NO) bioactivity. Since the vascular levels of O2•− are regulated
by the superoxide dismutase (SOD) enzymes, a role of SOD in the cardiovascular disease is
of substantial interest. Particularly, a major form of SOD in the vessel wall is the extracellular …
Abstract
Excessive production and/or inadequate removal of reactive oxygen species, especially superoxide anion (O2•−), have been implicated in the pathogenesis of many cardiovascular diseases, including atherosclerosis, hypertension, diabetes, and in endothelial dysfunction by decreasing nitric oxide (NO) bioactivity. Since the vascular levels of O2•− are regulated by the superoxide dismutase (SOD) enzymes, a role of SOD in the cardiovascular disease is of substantial interest. Particularly, a major form of SOD in the vessel wall is the extracellular SOD (ecSOD). This review will discuss the characteristics of ecSOD and the role of ecSOD in cardiovascular diseases.
Oxford University Press