Sodium channel mutations and susceptibility to heart failure and atrial fibrillation
TM Olson, VV Michels, JD Ballew, SP Reyna, ML Karst… - Jama, 2005 - jamanetwork.com
ContextDilated cardiomyopathy (DCM), a genetically heterogeneous disorder, causes heart
failure and rhythm disturbances. The majority of identified DCM genes encode structural
proteins of the contractile apparatus and cytoskeleton. Recently, genetic defects in calcium
and potassium regulation have been discovered in patients with DCM, implicating an
alternative disease mechanism. The full spectrum of genetic defects in DCM, however, has
not been established. ObjectivesTo identify a novel gene for DCM at a previously mapped …
failure and rhythm disturbances. The majority of identified DCM genes encode structural
proteins of the contractile apparatus and cytoskeleton. Recently, genetic defects in calcium
and potassium regulation have been discovered in patients with DCM, implicating an
alternative disease mechanism. The full spectrum of genetic defects in DCM, however, has
not been established. ObjectivesTo identify a novel gene for DCM at a previously mapped …