[HTML][HTML] Hepatic deficiency of low density lipoprotein receptor-related protein-1 reduces high density lipoprotein secretion and plasma levels in mice
JE Basford, L Wancata, SM Hofmann… - Journal of Biological …, 2011 - ASBMB
The low density lipoprotein receptor-related protein-1 (LRP1) is known to serve as a
chylomicron remnant receptor in the liver responsible for the binding and plasma clearance
of apolipoprotein E-containing lipoproteins. Previous in vitro studies have provided evidence
to suggest that LRP1 expression may also influence high density lipoprotein (HDL)
metabolism. The current study showed that liver-specific LRP1 knock-out (hLrp1−/−) mice
displayed lower fasting plasma HDL cholesterol levels when compared with hLrp1+/+ mice …
chylomicron remnant receptor in the liver responsible for the binding and plasma clearance
of apolipoprotein E-containing lipoproteins. Previous in vitro studies have provided evidence
to suggest that LRP1 expression may also influence high density lipoprotein (HDL)
metabolism. The current study showed that liver-specific LRP1 knock-out (hLrp1−/−) mice
displayed lower fasting plasma HDL cholesterol levels when compared with hLrp1+/+ mice …