RMSSD, a measure of vagus-mediated heart rate variability, is associated with risk factors for SUDEP: the SUDEP-7 Inventory

CM DeGiorgio, P Miller, S Meymandi, A Chin, J Epps… - Epilepsy & Behavior, 2010 - Elsevier
OBJECTIVE: The goal of this study was to determine if specific measures of heart rate
variability (HRV) are associated with the total score on a new seven-item inventory for
sudden unexplained death in epilepsy (SUDEP). METHODS: Nineteen subjects with
intractable partial seizures, at least three per month, were enrolled in a randomized clinical
trial of omega-3 fatty acids in epilepsy. At study entry, subjects underwent a 1-hour ECG
recording for the determination of HRV. To estimate the risk of SUDEP, we assembled a …