A new nucleic acid–based agent inhibits cytotoxic T lymphocyte–mediated immune disorders
CW Wang, WH Chung, YF Cheng, NW Ying… - Journal of allergy and …, 2013 - Elsevier
Background Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and graft-
versus-host disease (GVHD) are distinct immune reactions elicited by drugs or allogeneic
antigens; however, they share a pathomechanism with the activation of cytotoxic T
lymphocytes (CTLs). CTLs produce cytotoxic proteins, cytokines, chemokines, or immune
alarmins, such as granulysin (GNLY), leading to the extensive tissue damage and systemic
inflammation seen in patients with SJS/TEN or GVHD. Currently, there is no effective …
versus-host disease (GVHD) are distinct immune reactions elicited by drugs or allogeneic
antigens; however, they share a pathomechanism with the activation of cytotoxic T
lymphocytes (CTLs). CTLs produce cytotoxic proteins, cytokines, chemokines, or immune
alarmins, such as granulysin (GNLY), leading to the extensive tissue damage and systemic
inflammation seen in patients with SJS/TEN or GVHD. Currently, there is no effective …