[HTML][HTML] p300/β-catenin interactions regulate adult progenitor cell differentiation downstream of WNT5a/protein kinase C (PKC)
ME Rieger, B Zhou, N Solomon, M Sunohara… - Journal of Biological …, 2016 - ASBMB
Maintenance of stem/progenitor cell-progeny relationships is required for tissue
homeostasis during normal turnover and repair. Wnt signaling is implicated in both
maintenance and differentiation of adult stem/progenitor cells, yet how this pathway serves
these dichotomous roles remains enigmatic. We previously proposed a model suggesting
that specific interaction of β-catenin with either of the homologous Kat3 co-activators, p300
or CREB-binding protein, differentially regulates maintenance versus differentiation of …
homeostasis during normal turnover and repair. Wnt signaling is implicated in both
maintenance and differentiation of adult stem/progenitor cells, yet how this pathway serves
these dichotomous roles remains enigmatic. We previously proposed a model suggesting
that specific interaction of β-catenin with either of the homologous Kat3 co-activators, p300
or CREB-binding protein, differentially regulates maintenance versus differentiation of …