Emerging evidence on the role of the Hippo/YAP pathway in liver physiology and cancer
D Yimlamai, BH Fowl, FD Camargo - Journal of hepatology, 2015 - Elsevier
The Hippo pathway and its regulatory target, YAP, has recently emerged as an important
biochemical signaling pathway that tightly governs epithelial tissue growth. Initially defined
in Drosophilia, this pathway has shown remarkable conservation in vertebrate systems with
many components of the Hippo/YAP pathway showing biochemical and functional
conservation. The liver is particularly sensitive to changes in Hippo/YAP signaling with rapid
increases in liver size becoming manifest on the order of days to weeks after perturbation …
biochemical signaling pathway that tightly governs epithelial tissue growth. Initially defined
in Drosophilia, this pathway has shown remarkable conservation in vertebrate systems with
many components of the Hippo/YAP pathway showing biochemical and functional
conservation. The liver is particularly sensitive to changes in Hippo/YAP signaling with rapid
increases in liver size becoming manifest on the order of days to weeks after perturbation …