[HTML][HTML] Transforming growth factor-β1 induces expression of human coagulation factor XII via Smad3 and JNK signaling pathways in human lung fibroblasts
E Jablonska, P Markart, D Zakrzewicz… - Journal of biological …, 2010 - ASBMB
Coagulation factor XII (FXII) is a liver-derived serine protease involved in fibrinolysis,
coagulation, and inflammation. The regulation of FXII expression is largely unknown.
Transforming growth factor-β1 (TGF-β1) is a multifunctional cytokine that has been linked to
several pathological processes, including tissue fibrosis by modulating procoagulant and
fibrinolytic activities. This study investigated whether TGF-β1 may regulate FXII expression in
human lung fibroblasts. Treatment of human lung fibroblasts with TGF-β1 resulted in a time …
coagulation, and inflammation. The regulation of FXII expression is largely unknown.
Transforming growth factor-β1 (TGF-β1) is a multifunctional cytokine that has been linked to
several pathological processes, including tissue fibrosis by modulating procoagulant and
fibrinolytic activities. This study investigated whether TGF-β1 may regulate FXII expression in
human lung fibroblasts. Treatment of human lung fibroblasts with TGF-β1 resulted in a time …