Alteration of the cytotoxic action of sensitized lymphocytes by cholinergic agents and activators of adenylate cyclase
TB Strom, A Deisseroth, J Morganroth… - Proceedings of the …, 1972 - National Acad Sciences
TB Strom, A Deisseroth, J Morganroth, CB Carpenter, JP Merrill
Proceedings of the National Academy of Sciences, 1972•National Acad SciencesThe cytotoxic action of lymphocytes upon cells bearing alloantigens to which they are
sensitized is inhibited by agents that elevate intracellular amounts of 3′: 5′-cyclic AMP:
prostaglandin E1, cholera toxin, and theophylline. Cholinergic agents, added in the range of
1 to 100 pM, enhance cytotoxicity, an effect that is blocked by atropine. Because cholinergic
agents elevate cyclic GMP in other in vitro systems, these findings suggest that the cytotoxic
process effected by sensitized lymphocytes is a secretory phenomenon modulated by cyclic …
sensitized is inhibited by agents that elevate intracellular amounts of 3′: 5′-cyclic AMP:
prostaglandin E1, cholera toxin, and theophylline. Cholinergic agents, added in the range of
1 to 100 pM, enhance cytotoxicity, an effect that is blocked by atropine. Because cholinergic
agents elevate cyclic GMP in other in vitro systems, these findings suggest that the cytotoxic
process effected by sensitized lymphocytes is a secretory phenomenon modulated by cyclic …
The cytotoxic action of lymphocytes upon cells bearing alloantigens to which they are sensitized is inhibited by agents that elevate intracellular amounts of 3′:5′-cyclic AMP: prostaglandin E1, cholera toxin, and theophylline. Cholinergic agents, added in the range of 1 to 100 pM, enhance cytotoxicity, an effect that is blocked by atropine. Because cholinergic agents elevate cyclic GMP in other in vitro systems, these findings suggest that the cytotoxic process effected by sensitized lymphocytes is a secretory phenomenon modulated by cyclic AMP and cyclic GMP.
National Acad Sciences