Correlations between clinical patterns and causes of erythema multiforme majus, Stevens-Johnson syndrome, and toxic epidermal necrolysis: results of an …

A Auquier-Dunant, M Mockenhaupt, L Naldi… - Archives of …, 2002 - jamanetwork.com
Background It was proposed that Stevens-Johnson syndrome and toxic epidermal
necrolysis differed from erythema multiforme majus by the pattern and localization of skin
lesions. Objective To evaluate the validity of this clinical separation. Design Case-control
study. Settings Active survey from 1989 to 1995 of 1800 hospital departments in Europe.
Patients A total of 552 patients and 1720 control subjects. Methods Cases were sorted into 5
groups (erythema multiforme majus, Stevens-Johnson syndrome, Stevens-Johnson …