Rapid resolution of toxic epidermal necrolysis with anti-TNF-α treatment
RE Hunger, T Hunziker, U Buettiker… - Journal of allergy and …, 2005 - jacionline.org
To the Editor: Toxic epidermal necrolysis (TEN) is a rare, life-threatening, adverse drug
reaction characterized by widespread apoptosis and detachment of the epidermis. It is
associated with a high mortality rate of about 30%. Various drugs have been reported to
induce TEN (eg, antibiotics, anticonvulsants, and nonsteroidal anti-inflammatory drugs). The
optimal treatment modality is still highly debated. On the basis of recent reports, the
beneficial effect of intravenous immunoglobulin 1 has been challenged. 2 The cytokine TNF …
reaction characterized by widespread apoptosis and detachment of the epidermis. It is
associated with a high mortality rate of about 30%. Various drugs have been reported to
induce TEN (eg, antibiotics, anticonvulsants, and nonsteroidal anti-inflammatory drugs). The
optimal treatment modality is still highly debated. On the basis of recent reports, the
beneficial effect of intravenous immunoglobulin 1 has been challenged. 2 The cytokine TNF …