Allopurinol is the most common cause of Stevens-Johnson syndrome and toxic epidermal necrolysis in Europe and Israel

S Halevy, PD Ghislain, M Mockenhaupt… - Journal of the American …, 2008 - Elsevier
BACKGROUND: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN)
are rare severe cutaneous adverse reactions. OBJECTIVES: We sought to update
knowledge on the causes of SJS or TEN with a focus on the rate of allopurinol-associated
cases and to identify risk factors for allopurinol-associated SJS or TEN. METHODS: We
conducted a multinational case-control study. RESULTS: In all, 379 patients with severe
cutaneous adverse reactions validated as SJS or TEN and 1505 matched hospitalized …