[HTML][HTML] The Angiomotins–from discovery to function

S Moleirinho, W Guerrant, JL Kissil - FEBS letters, 2014 - Elsevier
S Moleirinho, W Guerrant, JL Kissil
FEBS letters, 2014Elsevier
Angiomotins were originally identified as angiostatin binding proteins and implicated in the
regulation of endothelial cell migration. Recent studies have shed light on the role of
Angiomotins and other members of the Motin protein family in epithelial cells and in
pathways directly linked to the pathogenesis of cancer. In particular, Motins have been
shown to play a role in signaling pathways regulated by small G-proteins and the Hippo–
YAP pathway. In this review the role of the Motin protein family in these signaling pathways …
Abstract
Angiomotins were originally identified as angiostatin binding proteins and implicated in the regulation of endothelial cell migration. Recent studies have shed light on the role of Angiomotins and other members of the Motin protein family in epithelial cells and in pathways directly linked to the pathogenesis of cancer. In particular, Motins have been shown to play a role in signaling pathways regulated by small G-proteins and the Hippo–YAP pathway. In this review the role of the Motin protein family in these signaling pathways will be described and open questions will be discussed.
Elsevier