Progress in the understanding of cardiac early afterdepolarizations and torsades de pointes: time to revise current concepts

PGA Volders, MA Vos, B Szabo, KR Sipido… - Cardiovascular …, 2000 - academic.oup.com
PGA Volders, MA Vos, B Szabo, KR Sipido, SHM de Groot, APM Gorgels, HJJ Wellens…
Cardiovascular research, 2000academic.oup.com
1. Introduction(electrical heterogeneity with nonuniform repolarization and refractoriness) for
the initiation and perpetuation of Afterdepolarizations are oscillations of the transmem-
torsades de pointes. brane potential that depend on the preceding action po- In this article,
we discuss the evidence for a new concept tential (AP) for their generation and can give rise
to new of EAD formation, which includes an important role for
1. Introduction(electrical heterogeneity with nonuniform repolarization and refractoriness) for the initiation and perpetuation of Afterdepolarizations are oscillations of the transmem- torsades de pointes. brane potential that depend on the preceding action po- In this article, we discuss the evidence for a new concept tential (AP) for their generation and can give rise to new of EAD formation, which includes an important role for
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