Human small intestinal epithelial cells secrete interleukin-7 and differentially express two different interleukin-7 mRNA Transcripts: implications for extrathymic T-cell …
L Madrigal-Estebas, R McManus, B Byrne, S Lynch… - Human immunology, 1997 - Elsevier
The small intestinal epithelium, composed of epithelial cells (EC) and intraepithelial T
lymphocytes, is exposed to numerous ingested antigens. Small intestinal EC may act as
accesory and/or antigen presenting cells for intestinal T cells, some of which may mature
extrathymically and regulate local immunity and tolerance. Since interleukin-7 (IL-7) plays
an essential role in T cell maturation and activation, we examined its expression by human
small intestinal EC. IL-7 was detected by ELISA in supernatants from 4 of 4 epithelial layer …
lymphocytes, is exposed to numerous ingested antigens. Small intestinal EC may act as
accesory and/or antigen presenting cells for intestinal T cells, some of which may mature
extrathymically and regulate local immunity and tolerance. Since interleukin-7 (IL-7) plays
an essential role in T cell maturation and activation, we examined its expression by human
small intestinal EC. IL-7 was detected by ELISA in supernatants from 4 of 4 epithelial layer …