Effective clearance of mouse hepatitis virus from the central nervous system requires both CD4+ and CD8+ T cells
JS Williamson, SA Stohlman - Journal of virology, 1990 - Am Soc Microbiol
JS Williamson, SA Stohlman
Journal of virology, 1990•Am Soc MicrobiolBoth CD4+ and CD8+ T cells are required for the clearance of virus from the central nervous
system following infection with the JHM strain of mouse hepatitis virus. Development of
antiviral antibodies requires the presence of CD4+ T cells but appears to play a minimal role
in the reduction of virus. The data presented are consistent with the hypothesis that
clearance of JHM virus is mediated by virus-specific CD8+ T cells, which appear to require
the presence of CD4+ T cells.
system following infection with the JHM strain of mouse hepatitis virus. Development of
antiviral antibodies requires the presence of CD4+ T cells but appears to play a minimal role
in the reduction of virus. The data presented are consistent with the hypothesis that
clearance of JHM virus is mediated by virus-specific CD8+ T cells, which appear to require
the presence of CD4+ T cells.
Both CD4+ and CD8+ T cells are required for the clearance of virus from the central nervous system following infection with the JHM strain of mouse hepatitis virus. Development of antiviral antibodies requires the presence of CD4+ T cells but appears to play a minimal role in the reduction of virus. The data presented are consistent with the hypothesis that clearance of JHM virus is mediated by virus-specific CD8+ T cells, which appear to require the presence of CD4+ T cells.
American Society for Microbiology