Background New-onset Alzheimer disease (AD) is often attributed to degenerative changes
in the hippocampus. However, the contribution of regionally distributed small vessel
cerebrovascular disease, visualized as white matter hyperintensities (WMHs) on magnetic
resonance imaging, remains unclear. Objective To determine whether regional WMHs and
hippocampal volume predict incident AD in an epidemiological study. Design A longitudinal
community-based epidemiological study of older adults from northern Manhattan, New York …