Outcomes after ecallantide treatment of laryngeal hereditary angioedema attacks

AL Sheffer, AJ MacGinnitie, M Campion… - Annals of Allergy …, 2013 - Elsevier
BACKGROUND: Hereditary angioedema (HAE) is a rare disorder associated with episodic
attacks of well-demarcated angioedema. Attacks that affect the larynx can result in life-
threatening airway obstruction. OBJECTIVES: To examine efficacy and safety of ecallantide
treatment for laryngeal HAE attacks. METHODS: Data were combined from 4 clinical studies
(EDEMA2, EDEMA3, EDEMA4, and DX-88/19) evaluating 30 mg of subcutaneous
ecallantide for treatment of acute HAE attacks. Efficacy was assessed using 2 validated …