Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition
RE Phillips, S Rowland-Jones, DF Nixon, FM Gotch… - Nature, 1991 - nature.com
Nature, 1991•nature.com
In a longitudinal study of HIV seropositive patients, there were fluctuations in the specificity
of cytotoxic T cells for the virus. This was matched by variability in proviral gag DNA epitope
sequences in the lymphocytes of these patients. Some of these viral variants are not
recognized by autologous T cells. Accumulation of such mutations in T-cell antigenic targets
would provide a mechanism for immune escape.
of cytotoxic T cells for the virus. This was matched by variability in proviral gag DNA epitope
sequences in the lymphocytes of these patients. Some of these viral variants are not
recognized by autologous T cells. Accumulation of such mutations in T-cell antigenic targets
would provide a mechanism for immune escape.
Abstract
In a longitudinal study of HIV seropositive patients, there were fluctuations in the specificity of cytotoxic T cells for the virus. This was matched by variability in proviral gag DNA epitope sequences in the lymphocytes of these patients. Some of these viral variants are not recognized by autologous T cells. Accumulation of such mutations in T-cell antigenic targets would provide a mechanism for immune escape.
nature.com